The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). I didnt intend to spend a lot of time on Steve in particular, but that video was so influential.. In some cases, youd want to taper down the dosage. They never make things worse so are safe to try. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. Added to FLCCC protocols and Fareed-Tyson protocol among others. There were IRB rules that required the 65 patients to be listed in the diagrams and charts. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. Now weve lost the high ground, Morris told me. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Here's why. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. P-value was 10^-14 on that study (done by Dr. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. My experience is very typical. Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . Get your prescription in advance of getting COVID. One Silicon Valley entrepreneur thought he could beat the odds. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. Medium revoked my account for life. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. Note that some of these articles are inaccurate. . Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. The sooner you start, the better the outcomes. Its not about the science. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. It cant be more clear than this. Can I see your risk-benefit analysis?. Proven in clinical use all over the world. skirsch.io. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Most doctors wont use it until NIH greenlights it, no matter what the science says. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. But Kirsch is also motivated by an unsatisfied competitive streak. The findings, published Wednesday in the New England Journal of Medicine, add to a growing body of scientific evidence pushing back against the use of the antiparasitic drug that has been promoted by some prominent voices on social media. This site requires JavaScript to run correctly. So far, doctors have failed to share his sense of urgency. . During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. . His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. 1:49 and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora ICER Publishes Final Evidence Report and Policy Recommendations on Outpatient Treatments for COVID-19 - ICER. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. Share this post. I fully expected both organizations to do absolutely nothing. Telling the truth, he tweeted. JAMA systematic review and meta analysis It doesnt get any better than this. But fear of trying something new prevents any doctor from giving this drug a try. In 2013, Johnson & Johnson paid $2.2 billion for its own kickback and fraud scandal, including a specific $400 million fine for its subsidiary Janssen, which manufactures the covid vaccine. No more. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). See this. Still, in the moment, his question threw me, and I stuttered. Everyone says "we need more data" to show fluvoxamine works for COVID. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. The next major effect is that that fluvoxamine activates the sigma-1 receptor. It does not matter how many lives will be saved. 95% confidence effect size is 75% or more. and increased heart rate (which could be nerves about the dilated pupils). Medicine isnt about saving lives anymore. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine Steve Kirsch's Newsletter ^ | 02/26/22 | Steve Kirsch. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. That covers almost 150,000 of them, which happened before vaccinations began. The drug was FDA-approved more than 65 years ago. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. Hes adept at debate, rapidly shifting the premise of a conversation to put the other person on the back foot. The results would, eventually, set Kirsch on a collision course with the scientific establishment. Im just telling you the truth. Jan 17. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. I took it myself at that dosage and noticed zero side effects. Kirsch did a lot of things right when he set up CETF. If you start later, doctors use higher dosages and compliance becomes a bigger problem. Everyone is stunned, but nobody is surprised. Its the gold standard of medical evidence. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Fluvoxamine, COVID, pandemic, . All the supporting observational studies were positive as well. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. He says that Facebook took down one of his posts announcing his appearance on 60 Minutes. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. Almost 2.5 million people signed up to Dr. B with the promise of getting leftover vaccines. But not 150K. It was completed in August. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. The track management was so impressed, they asked for prescriptions. Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. This looks ominous, but it harmless. The data is there in plain sight for anyone to see today. These people never called the researchers whose trials they claimed showed no effect. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. My favorite dosage is 50mg twice a day for 14 days. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. Boulware disputes that, and says that although Kirschs funding was important, his statements about drugs and vaccines have proven problematic. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? You cannot get any better than that. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. Its whether Merck can make a killing that matters. . But they dont want their names used. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. Or just depression about the vaccine mandates? That receptor also helps regulate the body's . He considers himself an expert in something that he doesnt have training or experience in, and hes not following scientific methods to assess data.. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Steve angrily decried this development as more evidence of FDA corruption. It never was. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. My favorite dosage is 50mg twice a day for 14 days. So it was both obvious and convincing the difference between the groups to the workers and the track management. Some are views most scientists think are wrong. For decades, coders wrote critical systems in C and C++. He was recently featured on 60 Minutes which highlighted his . His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. Refresh. Fluvoxamine has a 40 year safety track record. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. Added to FLCCC protocols and Fareed-Tyson protocol among others. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. I see it all the time on social media, Morris told me. If you cant lay off the java, then try fluoxetine (Prozac). About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. Online Status. In severe cases, it takes longer. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. 12:45 AM . We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. It will be months before enrollments are complete. . You can use fluoxetine as well (aka Prozac). Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. This was shown to be very tolerable (no side effects in 99% of patients) and extremely effective (no hospitalizations and death if you start it ASAP after first symptoms). All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. It's hard to ignore this lecture in explaining why the drug is so effective. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. Most recent articles first. I mean, he really, truly has a heart of gold, Char told me. Ive used it personally at 50mg twice a day and experience no adverse events at all. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. No long haul symptoms if you start the drug ASAP after first symptoms. Medium banned him for misinformation. Dosage there is 30mg once a day. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. They left their recommendation of fluvoxamine at NEUTRAL. Summary of key evidence. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. Theyre finding alternative leaders to follow, Morris said. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. 533. Hes spending his own money to do what he thinks is right. including the very promising Fluvoxamine. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. Vaccine waitlist Dr. B collected data from millions. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. Their willingness to lie did. Three of the four outpatient trials have been reported out: all were successful. See my article on treatments. I think we did rigorous reviews of proposals for research..

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